OVERVIEW

Titanium (Ti), its related alloys and other contemporary materials used by the dental implant industry are perceived to offer reasonable biocompatibility, mechanical properties and corrosion resistance, which renders them suitable for dental implants. 

However, the long-term operation of dental implants is challenged by implant-related infections, hardness and inadequate osseointegration. 

In circumstances involving peri-implantitis, although conventional therapy has the ability to decrease the population of several periodontal pathogens, microbiological parameters sometimes tend to revert to pretreatment values, showing elevated counts for several target microorganisms roughly 30 days after treatment. Irrespective of treatment effectiveness, prevention of implant failure by enhancing its performance with multifunctional antipathogenic quantum materials is of crucial importance. The coating of titanium and other forms of implants with antimicrobial nanomaterials should effectuate the prevention of infection and peri-implantitis and as a result, increase the succes rate of implants.

Avoiding implant failure is one of the fundamental reasons for surface modification of a dental implant because early bacterial colonisation can occur within minutes after implantation by microorganisms associated with periodontitis. 

Nanotechnology, enables the development of surface modifications that can mitigate these issues. These may be either in the form of:

•  implant composites enhanced with functional nanomaterials to improve antibacterial and immunomodulatory functions.

• the use of coatings that can provide mechanical wear and antipathogenic protection under dark operational conditions and masticatory loading

• integrating implants with mechanically- and bio-compatible materials that improve the osseointegration and soft-tissue integration of dental implants.

NANOARC Biomimetics uses nano-engineering to design and develop atomically-architectured functional and bio-compatible nanomaterials for topographical modifications and surface coatings of dental implants. Below is a layout of our offering to help dental implant manufacturers achieve essential improvement goals in their implants.

WHAT IS UNIQUE ABOUT Q-DENT?

The zone of inhibition (ZOI), is the clear zone surrounding an antimicrobial agent, indicating a complete absence of bacteria on, or within a given perimeter, from an antimicrobial agent. The size of a ZOI depends on the antimicrobial agent composition, particle size and concentration. Quantum materials distinguish themselves from regular materials in terms of their unique and elevated performance, under cirumstances that other materials cannot function in. For example, in antimicrobial settings, quantum materials perform in both illuminated and dark conditions while regular materials often need photo-activation, which is the predominant state of the mouth - dark.

The ZOI with quantum materials, can often double or even quadruple that of regular (nano)materials. With quantum materials, the ZOI can span several centimetres and dental fillings as well as implants can provide antimicrobial protection to adjacent teeth and deep into the root canal. This advantage, means merely coating an implant or adding Q-DENT nanoadditives to a dental filling at very low concentrations, makes it hard for bacteria to proliferate, within the mouth.

The nanoadditives we offer, can be used either as follows:

•  active components within the composite of dental implants for both antimicrobial protection and mechanical strength

•  active transparent nano-coatings. for antimicrobial protection and better osteoblast adhesion due to the biomimetic nature of the material, in promoting bone growth.

QUANT DENT

NANOARCHITECTURE : ~ 5nm (0.005 μm) spherical nanoparticles

SURFACE AREA (BET) : 41.53 m²/g 

COLOUR : White Nanopowder

DOSAGE IN IMPLANT OR  RESIN COMPOSITES :  on average 500 – 1000 μg/ml (or 0.5 - 1g per kg of composite mix)

DOSAGE IN IMPLANT COATING (min. bacteriostatic to max bactericidal concentration) :  300 – 1500 μg/ml 

APPLICATIONS : Anticorrosion, Antibacterial - effective against Streptococcus mutans, Enterococcus faecalis, Lactobacillus, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans. Anti-fungal, Suitable for resin fillings, prohibit of biofilm formation and inhibit hemolysis by hemolysin toxin produced by pathogens. Improves mechanical strength of tooth fillings and implants, osteogenic, Photoinitiator for photo-curable coatings, adhesives and dental restoratives.

QUANT DENT I 

NANOARCHITECTURE : Atomically Thin Sheets/Flakes ( < 1 nm Thickness)

SURFACE AREA (BET) : 63.52 m²/g

COLOUR : White Nanopowder

DOSAGE IN IMPLANT OR  RESIN COMPOSITES :  on average 300 – 700 μg/ml (or 0.3 - 0.7g per kg of composite mix)

DOSAGE IN IMPLANT COATING (min. bacteriostatic to max bactericidal concentration) :  250 – 1000 μg/ml 

APPLICATIONS : Enhanced UV curing (Photoinitiator for photo-curable coatings, adhesives and dental restoratives), to compensate for human error, Anticorrosion, Antibacterial - effective against Streptococcus mutans, Enterococcus faecalis, Lactobacillus, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, prohibit of biofilm formation and inhibit hemolysis by hemolysin toxin produced by pathogens. Anti-fungal, Pigment. Suitable for resin fillings and easy accessibility of ultra-small cracks and crevices in teeth. Improves mechanical strength of tooth fillings and implants, osteogenic.

QUANT DENT II  

NANOARCHITECTURE : Atomically Thin Sheets/Flakes ( < 1 nm Thickness)

SURFACE AREA (BET) : 70.30 m²/g

COLOUR : White Nanopowder

DOSAGE :  as needed

APPLICATIONS : Essential nano-biomineral useful for its osteogenic property and ability to form strong bonds with the host bone tissue. Drug delivery, implant material, to promote bone growth and repair lesions in tooth enamel. Impact-resistant material for composites, grinding media, antimicrobial filter material.